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  • Title: Hageman factor dependent activation and its relationship to lethal Pseudomonas aeruginosa burn wound infections.
    Author: Holder IA, Neely AN.
    Journal: Agents Actions Suppl; 1992; 38 ( Pt 3)():329-42. PubMed ID: 1462867.
    Abstract:
    Trauma causes increases in total protease load in the circulation of the traumatized host animal or patient. This increase is due, in part, to Hageman Factor activation followed by down-line cascade system activation. Concomitant with the activation of these systems is a reduced host capacity to resist infection. Infection superimposed on a traumatized host increases the total host protease load even more by additional activation of Hageman Factor and cascade systems.
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