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  • Title: The use of a mannitol-derived fused oxacycle as a combinatorial scaffold.
    Author: Timmer MS, Verdoes M, Sliedregt LA, van der Marel GA, van Boom JH, Overkleeft HS.
    Journal: J Org Chem; 2003 Nov 28; 68(24):9406-11. PubMed ID: 14629165.
    Abstract:
    An efficient and high-yielding solid-phase synthesis of a small library of compounds containing a cis-fused pyranofuran structural motive is described. With use of the cheap and readily available D-(+)-mannitol, a highly functionalized sugar template was synthesized and immobilized on a solid support via an olefinic linker. Modification of this two-point molecular scaffold and subsequent ring-closing metathesis/cleavage gave access to a series of functionalized conformationally constrained fused oxacycles.
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