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  • Title: Hepatitis C virus infection in Thai patients with oral lichen planus.
    Author: Klanrit P, Thongprasom K, Rojanawatsirivej S, Theamboonlers A, Poovorawan Y.
    Journal: Oral Dis; 2003 Nov; 9(6):292-7. PubMed ID: 14629329.
    Abstract:
    OBJECTIVE: Many studies focusing on the association between hepatitis C virus (HCV) infection and oral lichen planus (OLP) have been conducted. Diversities of geographical locations could be a major factor influencing the prevalence of HCV. This study was aimed to define whether there was a relationship between the OLP and HCV infection in Thailand. MATERIALS AND METHODS: Serum samples of 60 patients (with OLP) and 60 controls (without OLP), whose age and gender were matched, were respectively screened for anti-HCV by ELISA (third generation), and reverse transcription polymerase chain reaction (RT-PCR) for HCV-RNA. RESULTS: We found five patients (8.33%) with OLP infected with HCV: three patients were positive for both anti-HCV and HCV-RNA; one patient was only positive for anti-HCV; and one patient was only positive for HCV-RNA; whereas all the controls were negative for both anti-HCV and HCV-RNA (P=0.029). Three of five cases of OLP with HCV infection had histories of blood transfusions over 10 years ago. CONCLUSION: The present study reports a small, but statistically significant high prevalence of HCV infection among patients with OLP, although the underlying mechanism still remains unknown.
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