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  • Title: Determination of gatifloxacin in human serum and urine by high-performance liquid chromatography with ultraviolet detection.
    Author: Overholser BR, Kays MB, Sowinski KM.
    Journal: J Chromatogr B Analyt Technol Biomed Life Sci; 2003 Dec 05; 798(1):167-73. PubMed ID: 14630373.
    Abstract:
    A simple and sensitive HPLC method for the determination of gatifloxacin concentrations in human serum and urine was developed and validated. Serum proteins were removed by ultrafiltration through a filtering device after adding a displacing agent. Urine samples were diluted with mobile phase prior to injection. Separation was achieved with a C18 reverse-phase column and gatifloxacin concentrations were determined using ultraviolet detection. The quantitation limits of the assay were 100 ng/ml in serum and 1.0 microg/ml in urine. The assay method was successfully applied to a pharmacokinetic study of gatifloxacin in healthy volunteers.
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