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  • Title: [Sequelae of hypertension on end-organs of the brain].
    Author: Diener HC, Philipp T, Schrader J.
    Journal: Internist (Berl); 2003 Jul; 44(7):786-92. PubMed ID: 14631575.
    Abstract:
    Hypertension is the most important risk factor for stroke and vascular dementia. Antihypertensive treatment reduces stroke risk by 40%. Most probably all antihypertensive drugs are equally effective with the exception of alpha-blockers. Blood pressure is increased in many patients with acute stroke. In this phase sudden drops in blood pressure should be avoided. The combination of an ACE-inhibitor and a diuretic reduced strokes by 28% after TIA or a first stroke. Whether this is a drug specific effect or due to lowering blood pressure per se is investigated at the moment.
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