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  • Title: Synthesis and antibacterial activity of 1 beta-methyl-2-(5-substituted imidazolino pyrrolidin-3-ylthio)carbapenem derivatives.
    Author: Oh CH, Lee CS, Lee JS, Cho JH.
    Journal: Arch Pharm (Weinheim); 2003 Nov; 336(11):504-9. PubMed ID: 14639742.
    Abstract:
    The synthesis of a new series of 1 beta-methylcarbapenems containing a substituted imidazolino pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of the substituent on the imidazoline ring was investigated. Compound 13 g which has a N-sulfonylmethyl substituted imidazoline moiety showed the most potent antibacterial activity.
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