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  • Title: H2O2-induced platelet aggregation and increase in intracellular Ca2+ concentration are blocked by inhibitors of intracellular signaling.
    Author: Loiko EN, Samal AB, Shulyakovskaya SM.
    Journal: Biochemistry (Mosc); 2003 Nov; 68(11):1210-6. PubMed ID: 14640963.
    Abstract:
    Inhibitors of signaling enzymes such as guanosine-5;-O-2-thiodiphosphate, aristolochic acid, aspirin, indomethacin, and trifluoperazine block H2O2-induced platelet aggregation and H2O2-induced increase in the intracellular concentration of Ca2+. These findings suggest that the effect of H2O2 on platelets is associated with activation of signal pathways responsible for increase in the concentration of intracellular Ca2+. On H2O2-induced platelet aggregation, the concentration of cAMP in the cytoplasm decreases and that of cGMP increases.
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