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  • Title: Application of synthetic peptides to the diagnosis of neurocysticercosis.
    Author: Fleury A, Beltran C, Ferrer E, Garate T, Harrison LJ, Parkhouse RM, Garcia E, Fragoso G, Costa-Cruz J, Biondi G, Agapejev S, Sciutto E.
    Journal: Trop Med Int Health; 2003 Dec; 8(12):1124-30. PubMed ID: 14641848.
    Abstract:
    We tested the possible diagnostic utility of five Taenia saginata oncosphere-derived synthetic peptides in T. solium neurocysticercosis (NC). The five peptides correspond to protein sequences with high antigenic indexes that were cloned from a T. saginata oncosphere cDNA library. The test samples consisted of cerebrospinal fluid (CSF) samples randomly collected from patients referred from Mexican and Brazilian neurological institutes. Indirect enzyme-linked immunosorbent assays (ELISA) were carried out with the peptides either unconjugated or coupled to carrier proteins, and were compared with results obtained using T. solium cyst fluid as a positive control. For active inflammatory NC, the higher sensibility (93%) and specificity (85%) was obtained with peptides HP6-2 and Ts45W-1, respectively, coupled to ovalbumin, in both Mexican and Brazilian patients. Examining the results of the individual peptide assays in combination, in some instances, improved the sensitivity to 100%.
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