These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: TRALI after the transfusion of cross-match-positive granulocytes.
    Author: Sachs UJ, Bux J.
    Journal: Transfusion; 2003 Dec; 43(12):1683-6. PubMed ID: 14641864.
    Abstract:
    BACKGROUND: TRALI is a serious complication of transfusion. WBC antibodies have been associated with TRALI. The importance of such antibodies for the transfusion of granulocytes is unknown. CASE REPORT: A patient with hematologic malignancy and neutropenia-associated pneumonitis received 2 units of granulocytes despite a positive serologic cross- match. She developed severe TRALI after the second transfusion. RESULTS: The recipient's serum was reactive with immobilized HLA class I antigens from donor cells in a glycoprotein-specific assay. With an absorption-elution technique, at least anti-HLA-A2 could be identified as one of the donor-reactive antibodies in the recipient's serum. CONCLUSION: Granulocyte-reactive antibodies are associated with TRALI in an alloimmunized patient receiving granulocyte transfusions. Performing a cross-match procedure may be helpful in preventing severe pulmonary reactions. Additional data are required to determine whether cross-matching as a regular practice in granulocyte transfusions would be beneficial for patients.
    [Abstract] [Full Text] [Related] [New Search]