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  • Title: Protective antitumor immunity induced by fixed tumor cells in combination with adjuvant in a murine hepatoma model.
    Author: Huang L, Ohno T.
    Journal: Cancer Lett; 2003 Dec 30; 202(2):153-9. PubMed ID: 14643445.
    Abstract:
    We previously reported that fixed tumor sections induced autologous cytotoxic T lymphocytes (CTL) from human peripheral blood lymphocytes in vitro. Here, we examined whether fixed tumor cells could stimulate in vivo immunity using a murine hepatoma model. Vaccination of syngeneic mice with fixed Hepa 1-6 cells in combination with OK-432 and tuberculin as an adjuvant resulted in a significant increase in survival of mice against live Hepa 1-6 cell challenge. In addition, the splenocytes from vaccinated mice secreted CD4(+) T cell-mediated interferon-gamma (IFN-gamma) and exhibited a specific CTL response. These findings suggest that fixed tumor cells combined with an appropriate adjuvant induce effective antitumor immunity in vivo.
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