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  • Title: Differential effect of fetal, neonatal and treatment variables on neurodevelopment in infants with congenital hypothyroidism.
    Author: Alvarez M, Carvajal F, Renón A, Pérez C, Olivares A, Rodríguez G, Alvarez V.
    Journal: Horm Res; 2004; 61(1):17-20. PubMed ID: 14646397.
    Abstract:
    OBJECTIVES: To identify the influence of fetal, neonatal and treatment variables on neurodevelopment in children with congenital hypothyroidism. METHODS: A multiple regression analysis was performed in the neurodevelopmental scores of 26 children with CH who were assessed at 3, 6, 12 and 18 months for postural control, fine eye-hand coordination and language. The independent variables were: duration of fetal hypothyroidism, initial biochemical severity, days at starting treatment, initial dose, and efficiency of treatment. RESULTS: Postural control was predicted by duration of fetal hypothyroidism and language by the biochemical severity of the disease at birth. Fine eye-hand coordination was not predicted by any variable. CONCLUSION: This pattern of influences suggests that fetal and neonatal hypothyroidism have different effects on brain maturation sites during the first 2 years of life and that some subtle neurocognitive deficits are probably unavoidable.
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