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  • Title: Is retinopathy of prematurity increasing among infants less than 1250 g birth weight?
    Author: O'Connor MT, Vohr BR, Tucker R, Cashore W.
    Journal: J Perinatol; 2003 Dec; 23(8):673-8. PubMed ID: 14647167.
    Abstract:
    OBJECTIVE: Retinopathy of prematurity (ROP) is a complication seen in many very low birth weight infants. Severe ROP has been called a "marker" for severe disability. The purpose of this study was to evaluate the occurrence and severity of ROP among infants < or =1250 g birth weight treated in the Special Care Nursery at Women & Infants' Hospital over a period of 7 years from 1994 to 2000. STUDY DESIGN: This was a retrospective review of ROP data combined with neonatal follow-up data. Of the 1002 infants born with birth weights <1250 g, ophthalmologic data were available for 739 of 839 survivors. Analysis of variance and chi2 along with logistic regression were used to analyze outcomes. RESULTS: An increase in the overall occurrence of ROP was identified (40% to 54% linear trend, p=0.007). The occurrence of threshold ROP ranged from 2% to 5% (NS). Infants at greatest risk of ROP were those micropremies with birth weights <750 g (p<0.001). CONCLUSION: Severe ROP continues to be a significant morbidity among infants <750 g.
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