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  • Title: HLA in Singapore Chinese with rheumatoid arthritis.
    Author: Boey ML, Wee GB, Mohan C, Howe HS, Chan SH, Feng PH.
    Journal: J Rheumatol; 1992 Oct; 19(10):1517-9. PubMed ID: 1464861.
    Abstract:
    The HLA-A, B, C, DR and DQ antigens were determined in 50 Singapore Chinese patients with rheumatoid arthritis (RA). There was a significant increase in the prevalence of HLA-Bw46, DRw53 and DQ3 in patients with RA. The linkage disequilibrium between Bw46 and DRw53 explains this association. This major histocompatibility complex association differs from the HLA-DR4 link in Caucasian populations and suggests that RA is an immunogenetically heterogeneous disease.
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