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  • Title: Optic nerve glioma in Japanese patients with neurofibromatosis 1. Case reports and literature review.
    Author: Hayasaka S, Miyagawa M, Ugomori S, Noda S, Setogawa T, Kagawa T, Yamasaki T, Miura H.
    Journal: Jpn J Ophthalmol; 1992; 36(3):315-22. PubMed ID: 1464971.
    Abstract:
    Case 1, a 6-year-old boy, had multiple café-au-lait spots, no light perception OS, Lisch nodules OU, pale optic disc OS, enlarged left optic nerve on computed tomographic scan and magnetic resonance imaging, and histopathologically verified pilocytic astrocytoma (glioma). The patient's mother had neurofibromatosis 1 (NF-1). Case 2, a 12-year-old boy, had multiple café-au-lait spots, decreased visual acuity OU, Lisch nodules OU, pale optic discs OU, enlarged optic nerves and chiasm on computed tomographic scan, and histopathologically verified pilocytic astrocytoma. We also examined 38 Japanese patients with NF-1 and found Lisch nodules in 95% and optic nerve glioma in 5%. After reviewing the recent literature, we found that the association of optic nerve glioma and NF-1 in the Japanese population was less than that reported in North America.
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