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  • Title: [CCR5, a new target of anti-HIV drugs].
    Author: Han YX, Jiang JD.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2003 Oct; 25(5):635-9. PubMed ID: 14650176.
    Abstract:
    CCR5, a membrane protein on cell surface, is a member of the G protein-coupled receptor superfamily and one of the major co-receptors for HIV-1 infection. The roles of CCR5 in HIV-1 infection have been elucidated since 1996. Because of the biological nature of CCR5, it has became a molecular target for the novel drugs against HIV-1. Antagonists for CCR5 could be grouped as following, chemokine derivatives, small molecule non-peptide compounds, monoclonal antibodies and peptides. The latest progress in this field is reviewed in this article.
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