These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Expression of matrix metalloproteinase-3 and tissue inhibitor metalloproteinases-1 in regenerated rabbit bone after mandibular osteodistraction].
    Author: Zou S, Wang Z, Hu J.
    Journal: Hua Xi Kou Qiang Yi Xue Za Zhi; 2003 Oct; 21(5):342-3, 363. PubMed ID: 14650982.
    Abstract:
    OBJECTIVE: To observe the expression patterns of matrix metalloproteinase-3 and its inhibitor, tissue inhibitor metalloproteinases (TIMP)-1, in remodeling phase of mandibular distraction osteogenesis. METHODS: Bilateral mandibular osteotomies were performed in 8 mature rabbits. The mandibles were lengthened 6 mm using a custom-made distractor with a rate of 1 mm/d. All animals were killed in 4 weeks after completion of distraction. The distracted calluses were harvested and processed for histology and immunohistochemistry of MMP-3 and TIMP-1. RESULTS: Elevated expression of both MMP-3 and TIMP-1 was found in the distracted calluses resulting from mandibular lengthening. Positive staining for MMP-3 was seen in the osteoblasts and osteocytes, and TIMP-1 was mainly localized in osteoblasts. CONCLUSION: MMP-3 and TIMP-1 appear to play important roles in the remodeling of new bone created by mandibular distraction osteogenesis.
    [Abstract] [Full Text] [Related] [New Search]