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  • Title: Immunocytochemical localization of neurons containing the AMPA GluR2/3 subunit in the hamster visual cortex.
    Author: Ryoo SR, Ahn CH, Lee JY, Kang YS, Jeon CJ.
    Journal: Mol Cells; 2003 Oct 31; 16(2):211-5. PubMed ID: 14651263.
    Abstract:
    AMPA glutamate receptors play a crucial role in brain functions such as synaptic plasticity and development. We have studied the chemo-architecture of the AMPA glutamate receptor subtype GluR2/3 in the hamster visual cortex by immunocytochemistry and compared it with the distribution of the calcium-binding proteins, calbindin D28K and calretinin. Anti-GluR2/3-immunoreactive (IR) neurons were predominantly located in layers II/III, V, and VI, and the majority of the labeled neurons were round or oval. However, many pyramidal cells in layer V were also labeled. Two-color immunofluorescence revealed that none of the GluR2/3-IR neurons contained calbindin D28 K or calretinin. Thus specific layers of neurons express the GluR2/3 subunit and these do not correlate with expression of calbindin D28K and calretinin.
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