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  • Title: Re-evaluation of reading frame-shift hypothesis in Duchenne and Becker muscular dystrophy.
    Author: Pandey GS, Kesari A, Mukherjee M, Mittal RD, Mittal B.
    Journal: Neurol India; 2003 Sep; 51(3):367-9. PubMed ID: 14652441.
    Abstract:
    The reading frame hypothesis has been proposed to explain the molecular basis of two allelic forms of muscular dystrophies, Duchenne/Becker muscular dystrophy (D/BMD). To evaluate the hypothesis in Indian D/BMD patients, we analyzed deletion of dystrophin exons in 147 DMD and 19 BMD patients. Our studies showed deviation of more than 30% from the reading frame hypothesis in DMD patients (47/147). The present results implicate a need to reevaluate the reading frame hypothesis.
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