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  • Title: The transition from relapsing-remitting MS to irreversible disability: clinical evaluation.
    Author: Trojano M, Paolicelli D, Bellacosa A, Cataldo S.
    Journal: Neurol Sci; 2003 Dec; 24 Suppl 5():S268-70. PubMed ID: 14652786.
    Abstract:
    The development of a progressive course is by far the most deleterious event in the case of a multiple sclerosis (MS) patient. It occurs in about 90% of relapsing remitting patients by 20-25 years from onset. The clinical transition to secondary progressive MS is phenotypically distinctive and both patients and physicians acknowledge that a fundamental shift in the degree of responsiveness to anti-inflammatory therapies has occurred. This review discusses the clinical studies that provided important findings relating to our understanding on different mechanisms that may contribute to irreversible disability in MS.
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