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  • Title: [Study of the antihypoxic effect of eburnamonine in acute and recurrent anoxia on the cerebral electric activity in curarized rats. Comparison with vincamine].
    Author: Van Den Driessche J, Linée P, Lacroix P, Le Pollès JB.
    Journal: C R Seances Soc Biol Fil; 1977; 171(5):1081-7. PubMed ID: 146550.
    Abstract:
    Using venous infusion (0.25 mg/kg min.), l-eburnamonine decreases the electroencephalographic modifications induced by acute asphyxic anoxia in curarized rats. This activity appears when the total dose administrated before the first asphyxia is approximatively 5 mg/kg. In such conditions, its protective activity is precocious and long lasting. In the same experimental conditions, vincamine assumes a protective activity only during a short time. The results are discussed in terms of selectivity of the method used and in terms of cerebral antihypoxic properties of l-eburnamonine.
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