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  • Title: The direct organocatalytic asymmetric mannich reaction: unmodified aldehydes as nucleophiles.
    Author: Notz W, Tanaka F, Watanabe S, Chowdari NS, Turner JM, Thayumanavan R, Barbas CF.
    Journal: J Org Chem; 2003 Dec 12; 68(25):9624-34. PubMed ID: 14656087.
    Abstract:
    The unprecedented application of unmodified aldehydes as nucleophilic donors in direct catalytic asymmetric Mannich-type reactions is disclosed in a full account. Our efforts in broadening the applicability of chiral pyrrolidine-based catalysts in direct asymmetric Mannich-type reactions led to the highly diastereo- and enantioselective and concise synthesis of functionalized alpha- and beta-amino acids, beta-lactams, and amino alcohols.
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