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  • Title: Structure-activity relationship studies of illudins: analogues possessing a spiro-cyclobutane ring.
    Author: McMorris TC, Cong Q, Kelner MJ.
    Journal: J Org Chem; 2003 Dec 12; 68(25):9648-53. PubMed ID: 14656090.
    Abstract:
    Bicyclic and tricyclic analogues of anticancer sesquiterpene illudin S have been synthesized. These contain a spiro-cyclobutane instead of spiro-cyclopropane structure. The cytotoxicity of the former is less than that of the corresponding cyclopropane-containing compounds.
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