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  • Title: Maternal sex hormones in early pregnancy and asthma among offspring: a case-control study.
    Author: Xu B, Pekkanen J, Husman T, Keski-Nisula L, Koskela P.
    Journal: J Allergy Clin Immunol; 2003 Dec; 112(6):1101-4. PubMed ID: 14657866.
    Abstract:
    BACKGROUND: Sex hormones may be associated with the risk of onset of asthma. OBJECTIVE: To study the association between maternal sex hormone concentrations during early pregnancy and the risk of asthma among offspring. METHODS: A case-control study of 129 asthmatic children and 125 control children 5 to 6 years of age. Maternal sera in early pregnancy were obtained from the Finnish Maternal Cohort serum bank. RESULTS: The means of serum progesterone and estradiol and free estradiol in mothers of asthmatic and control children were 81.0 and 82.8 nmol/L (P =.60), 7.87 nmol/L and 7.65 nmol/L (P =.99), and 149.5 pmol/L and 148.0 pmol/L (P =.95), respectively. There were also no differences in the mean concentrations of maternal sex hormones according to the presence of allergic rhinitis or atopic eczema among the children. CONCLUSIONS: The current results do not support an association between maternal sex hormone concentrations during early pregnancy and onset of allergic disease in early childhood.
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