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  • Title: Assessing clinically relevant cognitive decline: preliminary data on a new method.
    Author: Isella V, Atzeni L, Iurlaro S, Villa ML, Russo A, Forapani E, Frattola L, Appollonio IM.
    Journal: Neurol Sci; 2003 Nov; 24(4):236-41. PubMed ID: 14658039.
    Abstract:
    Physiological age-related cognitive decline, practice effect and regression to the mean may interfere with the interpretation of psychometric changes between subsequent neuropsychological evaluations. The standardized regression-based (SRB) change score allows investigators to define clinically relevant cognitive change on an individual basis controlling for these confounding factors. We performed a preliminary study to test its applicability and usefulness in the neuropsychological diagnosis of dementia. We derived a regression equation for the tests of a widely used Italian battery for global cognitive assessment, the Mental Deterioration Battery, in a sample of 20 normal elderly and we tested the potential clinical application of the SRB methodology in two cases of questionable dementia.
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