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  • Title: [The electro-physiological change of guinea pig cochlea caused by intracochlear perfusion of sodium salicylate].
    Author: Zhang S, Robertson D.
    Journal: Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2003 Sep; 17(9):551-3. PubMed ID: 14658194.
    Abstract:
    OBJECTIVE: To investigate the way how sodium salicylate affects cochlear function and discuss its possible mechanism. METHOD: Sodium salicylate was perfused through guinea pig cochlea. The thresholds and input-output (I/O) functions of compound action potential (CAP) and summating potential (SP) were monitored during the perfusion. RESULT: Sodium salicylate caused a significant change of CAP and SP threshold as well as I/O curve. The relationship between CAP and SP threshold change at 10 kHz during perfusion with 10 mmol/L salicylate tends to be 1:1. CONCLUSION: Outer hair cells are most likely to be the sites of action of sodium salicylate and this action on the outer hair cell active process might lead to its ototoxicity.
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