These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of anti-HLA and anti-idiotypic antibodies on the long-term survival of heart and kidney allografts.
    Author: Reed E, Cohen DJ, Barr ML, Ho E, Marboe CC, Rose EA, Hardy M, Suciu-Foca N.
    Journal: Transplant Proc; 1992 Dec; 24(6):2494-5. PubMed ID: 1465842.
    Abstract:
    Long-term survival of heart and kidney allografts is threatened by the development of chronic rejection. Analysis of the relationship between reversible acute rejection episodes and actuarial survival at 5 years showed an inverse correlation suggesting that early cellular events may trigger antibody-mediated chronic rejection. In both heart and kidney allograft recipients producing anti-HLA antibodies we found a significant decrease in the 5-year graft survival rate. However, there was heterogeneity among anti-HLA antibody producers with respect to the development of anti-idiotypic antibodies. The actuarial 5-year graft survival was significantly higher in patients with Ab2 compared to patients without.
    [Abstract] [Full Text] [Related] [New Search]