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  • Title: [Expression of vascular endothelial growth factor during mandibular distraction osteogenesis in rabbits].
    Author: Tang J, Hu J, Wang ZG, Gao ZW, Li JH.
    Journal: Shanghai Kou Qiang Yi Xue; 2003 Jun; 12(3):191-3. PubMed ID: 14661327.
    Abstract:
    OBJECTIVE: To investigate the expression pattern of vascular endothelial growth factor (VEGF) in the distracted callus during mandibular osteodistraction. METHODS: Bilateral mandibular osteotomies were performed in 12 rabbits. 3 rabbits were sacrificed respectively at 0, 7, 14 and 28 days after completion of distraction. The newly formed calluses were harvested and processed for histology and immunohistochemistry of VEGF. RESULTS: Intense angiogenesis was observed in the regenerated callus after mandibular lengthening, and positive staining for VEGF was mainly noted in vascular endothelial cells and the active osteoblasts. CONCLUSIONS: Mechanical strain created by distraction led to angiogenesis in distraction gap. VEGF may play a critical role in angiogenesis and subsequent osteogenesis during mandibular lengthening.
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