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  • Title: Role of epicardial QT intervals in the assessment of ventricular repolarisation dispersion.
    Author: Wang L.
    Journal: Gen Physiol Biophys; 2003 Jun; 22(2):213-20. PubMed ID: 14661733.
    Abstract:
    The role of cardiac surface QT intervals (QTI) in assessing ventricular repolarisation dispersion was investigated in 10 pentobarbital-anesthetized, open-chest sheep. Activation-recovery interval (ARI) and QTI were measured from multiple ECGs acquired from left ventricular epicardium, before and after procainamide administration (15 mg/min i.v. for 20 min). Procainamide therapy resulted in a significant prolongation in ARI and corrected QT interval (cQTI). A correlation between QTI, cQTI and ARI was found in only one animal (r = 0.78 and 0.79 respectively, p = 0.01) before procainamide therapy. No correlation was found between pooled QTI and ARI dispersion from the 10 animals at baseline or after procainamide administration (p > 0.05). There was a moderate correlation between pooled cQTI and ARI dispersion (r = 0.69, p = 0.02) before procainamide therapy. In conclusion, epicardial QTI have no significant correlation with the duration of ventricular repolarisation. Epicardial QTI dispersion is not a useful index of repolarisation heterogeneity.
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