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  • Title: Synthesis of some functionalized arylaminomethyl-1 ,2,4-triazoles, 1,3,4-oxa- and thiadiazoles.
    Author: Abdel-Aal MT, El-Sayed WA, Abdel Aleem AH, El Ashry ES.
    Journal: Pharmazie; 2003 Nov; 58(11):788-92. PubMed ID: 14664332.
    Abstract:
    Thiosemicarbazides undergo different cyclization reactions to give five membered heterocycles. The product of cyclization depends on the reagent used. This cyclization leads to the formation of 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole derivatives. The reaction of thioglycolyl hydrazide derivatives of the 1,2,4-triazole compounds was discussed. The activity against hepatitis B virus (HBV) has been tested.
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