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  • Title: Functionalization of the alicyclic skeleton of epibatidine: synthesis and nicotinic acetylcholine receptor binding affinities of epibatidine analogues.
    Author: Wei ZL, Xiao Y, George C, Kellar KJ, Kozikowski AP.
    Journal: Org Biomol Chem; 2003 Nov 21; 1(22):3878-81. PubMed ID: 14664377.
    Abstract:
    A novel method for the epimerization of endo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptan-3-one (12) on silica gel was developed and used as the key step to synthesize functionalized analogues of epibatidine which were evaluated for their nicotine receptor subtype selectivity in binding studies.
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