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  • Title: Effect of transferring frozen-thawed embryos resulting from fertilization of immature oocytes matured one day in culture prior to intracytoplasmic sperm injection (ICSI) on implantation rates.
    Author: Check JH, Swenson K, Summers-Chase D, Choe JK, Yuan W.
    Journal: Clin Exp Obstet Gynecol; 2003; 30(4):197-8. PubMed ID: 14664410.
    Abstract:
    PURPOSE: To evaluate whether it is efficacious to allow immature (metaphase I or germinal vesicle stage) oocytes to incubate one more day and then perform ICSI. METHOD: A retrospective study of frozen embryo transfers (ET) of deselected frozen embryos was performed to see if inclusion of a higher percentage of embryos derived from in vitro maturation of oocytes resulted in lower implantation rates. RESULTS: The implantation rate following transfer of frozen-thawed embryos, where embryos derived from immature oocytes constituted < or = 40% of the embryos (group 1) was similar to group 2 with > 40% (11.3% vs 9.8%). However, group 1 had a 10.2% implantation rate for viable (past first trimester) sacs vs only 4.3% for group 2. CONCLUSIONS: Pregnancies from transfer of frozen-thawed embryos derived from in vitro cultured immature oocytes are as likely to implant as the other deselected frozen-thawed embryos.
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