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  • Title: Effects of UFT on thymidylate synthase and dihydropyrimidine dehydrogenase activities in lung cancer.
    Author: Miyamoto H, Morio A, Izumi H, Yamazaki A, Wang Z, Futagawa T, Sonobe S.
    Journal: Anticancer Res; 2003; 23(5b):4153-6. PubMed ID: 14666617.
    Abstract:
    BACKGROUND: We measured thymidylate synthase (TS) activity, dihydropyrimidine dehydrogenase (DPD) activity and TS inhibition rate (TSIR) in tumor tissue and lymph node metastasis, considered predictors of response to DIFs, in patients with lung cancer. PATIENTS AND METHODS: Fourteen patients with non-small cell lung cancer (NSCLC) were given UFT for 1-2 weeks before surgery. Total TS activity (total TS), TSIR and DPD activity were measured in tumors, lymph node metastases and normal lung and lymph nodes. RESULTS: Total TS activity and DPD activity were significantly higher in lung tumors than in normal lung (TS, p = 0.0225; DPD, p < 0.0001). Total TS activity was slightly but not significantly higher in lymph node metastases than in normal lymph nodes. DPD activity and TSIR were similar in the other tissues. CONCLUSION: After preoperative treatment with UFT, TS and DPD activities are significantly higher in lung tumor tissue than in normal lung tissue in patients with NSCLC.
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