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  • Title: Cerebral anaplastic pleomorphic xanthoastrocytoma with meningeal dissemination at first presentation.
    Author: Lubansu A, Rorive S, David P, Sariban E, Seligmann R, Brotchi J, Pirotte B.
    Journal: Childs Nerv Syst; 2004 Feb; 20(2):119-22. PubMed ID: 14669022.
    Abstract:
    INTRODUCTION: Pleomorphic xanthoastrocytoma (PXA) is a rare brain glial tumour found in young patients. Most cases are reported as evolving low-grade neoplasms associated with a long survival after complete surgical resection. Some PXAs, however, can demonstrate secondary malignant transformation or progress with a short survival. Anaplastic histological features at first presentation or secondary meningeal dissemination have rarely been reported. CASE REPORT: We describe the case of a cerebral PXA in a 7-year-old girl presenting with anaplastic histological features and craniospinal meningeal dissemination that progressed rapidly with a poor outcome.
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