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  • Title: [Study on exons 3 and 4 of alpha-synuclein gene in Chinese familial Parkinson disease patients].
    Author: Chen X, Liu YT, Li JR, Chen L, Xu YM, Pan YH, Meng XH, Xing SH.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2003 Dec; 20(6):536-8. PubMed ID: 14669226.
    Abstract:
    OBJECTIVE: To study the relationship of Chinese familial Parkinson disease with alpha-synuclein gene. METHODS: Polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) and polymerase chain reaction-heteroduplex analysis(PCR-HA) were employed to detect the abnormal mobilization in the familial Parkinson disease and sporadic Parkinson disease patients, then it was verified by gene sequencing. RESULTS: No mutation was found in alpha-synuclein gene exons 3 and 4 by PCR-SSCP together with PCR-HA. An inserted c and an inserted t were found in intron 4, position 23 and position 67 respectively. CONCLUSION: (1) Exons 3 and 4 of alpha-synuclein gene are not the mutational hot spots of Chinese familial Parkinson disease. (2) Two polymorphisms were found in intron 4 of alpha-synuclein gene. They are 23 ins c and 67 ins t.
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