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  • Title: [Neutrophilic and lymphocytic factors of an immune response in renal tuberculosis].
    Author: Iagafarova RK, Potapenko EI, Shenderova RI, Iakunova OA, Korolenok OL, Kusursuz MO, Sushkova EA.
    Journal: Probl Tuberk Bolezn Legk; 2003; (10):27-30. PubMed ID: 14669626.
    Abstract:
    Fifty-eight patients with nephrotuberculosis at its peak were found to have a high functional activity of neutrophilic granulocytes, as determined by the lysosomal cation test, by the levels of myeloperoxidase and lactoferrin. The subpopulation of lymphocytes, concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), as well as those of IL-2 in a combination with its soluble receptor (SR-2) in the serum and supernatant of cellular cultures stimulated by phytohemagglutitin and PPD were studied. The findings suggest that there is a close correlation between the high concentrations of IL-2 and PP-alpha and the decreased content of activated lymphocytes expressing receptors to IL-2 (CD25+). Clinical remission has been ascertained to be attended only by a partial normalization of immunological parameters with antituberculous therapy.
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