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  • Title: [Carnosine and anserine as specialized pH-buffers--hydrogen ion carriers].
    Author: Skulachev VP.
    Journal: Biokhimiia; 1992 Sep; 57(9):1311-6. PubMed ID: 1467351.
    Abstract:
    Data are reviewed that carnosine (pK 6.9) and anserine (pK 7.1) act as specific mobile pH buffers promoting a rapid elimination of pH gradients between different parts of muscle fibers (very large cells containing various structural components, such as actomyosin, Z-discs, mitochondrial and sarcoplasmic reticulum, etc.). The specific role of these muscle dipeptides as pH buffers (H(+)-translocators) provides explanation for the so-called "Severin phenomenon"-a manyfold enhancement by carnosine of the ability of the isolated muscle to contract and accumulate lactate.
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