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  • Title: The cerebellum and cognition. Intellectual function in spinocerebellar ataxia type 6 (SCA6).
    Author: Globas C, Bösch S, Zühlke Ch, Daum I, Dichgans J, Bürk K.
    Journal: J Neurol; 2003 Dec; 250(12):1482-7. PubMed ID: 14673583.
    Abstract:
    The aim of this study was to assess cognitive function in patients with spinocerebellar ataxia type 6 (SCA6), an autosomal-dominantly inherited disease leading to a progressive cerebellar syndrome. In contrast to other SCA types, the pathological changes are mostly restricted to the cerebellum. Cognitive function was studied in 12 patients with genetically confirmed SCA6 (mean duration of disease: 9.2 +/- 11.6 years) and 12 age- and IQ-matched controls using a test battery comprising tests for IQ, attention, verbal and visuospatial memory, as well as executive function. While none of the SCA6 subjects had features of general intellectual impairment, only mild deficits in single subtests especially in fronto-executive tasks were observed, but without reaching statistical significance. Thus the current findings do not demonstrate severe cognitive dysfunction in SCA6.
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