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  • Title: [Myopathy associated with infection by the human immunodeficiency virus type-1 (HIV-1)].
    Author: Gabriel Botella F, Rosello Sastre E, Labios Gómez M, Carda Batalla C, Balaguer Martínez JV, Arnal Babiloni M.
    Journal: An Med Interna; 1992 Nov; 9(11):557-9. PubMed ID: 1467406.
    Abstract:
    We present a case of an active homosexual patient who was a paid donor of plasma and presented myopathy associated to infection by the human immunodeficiency virus type 1 (HIV-1). In the ultrastructural study of the muscular biopsy, we stress the formation of central intermyofibrillary "minocores", as well as the presence of nuclear extrusions in which the core is surrounded by mitochondrial accumulations. We review the clinical, histological and ultrastructural characteristics used to identity this pathology against the group of myopathies induced by zidovudine, as well as the several empirical therapies currently recommended.
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