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  • Title: Time correction for computing Michaelis--Menten kinetics.
    Author: Rodriguez F, Prats M.
    Journal: Comput Appl Biosci; 1992 Dec; 8(6):575-7. PubMed ID: 1468014.
    Abstract:
    A description of time correction applied to the integrated Michaelis equation in view of cancelling a non-correct estimation of the Michaelis constant due to a lack of coincidence between time zero of measurement and time zero of reaction is presented. An estimation of kinetic parameters is made with time correction on the same experimental set of data using a classical least squares iterative procedure.
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