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  • Title: Glial localization of interleukin-1 alpha in invertebrate ganglia.
    Author: Paemen LR, Porchet-Hennere E, Masson M, Leung MK, Hughes TK, Stefano GB.
    Journal: Cell Mol Neurobiol; 1992 Oct; 12(5):463-72. PubMed ID: 1468116.
    Abstract:
    1. Mytilus pedal ganglion contains a small population of glial cells that are immunopositive for interleukin-1 alpha. Positively stained fibers can also be seen in the neuropil of these sections. 2. The marine worm Nereis diversicolor also exhibits positive neural immunostaining for interleukin-1 alpha. 3. Both organisms contain hemocytes that contain immunoactivity for interleukin-1 alpha. The study suggests interleukin-1 alpha to be an ancient cytokine given its presence in organisms that evolved significantly earlier than mammals.
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