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  • Title: Effect of prostaglandin synthesis inhibition on glomerular filtration rate in renal transplant recipients.
    Author: Marín C, Herrera J, Manzanares J, Rodríguez-Iturbe B.
    Journal: Clin Nephrol; 1992 Dec; 38(6):329-33. PubMed ID: 1468164.
    Abstract:
    To determine the influence of prostaglandin (PG) synthesis inhibition on the renal function in renal transplant recipients, we carried out a crossover, double-blind, placebo controlled study of 18 ambulatory patients. Glomerular filtration rate (GFR) was measured using 51-Cr EDTA, before and after indomethacin (50 mgr. three times a day for three days), and placebo. Overnight urinary PGE excretion decreased 88.9 +/- SEM 4.81% after indomethacin, but remained unchanged following placebo. GFR decreased 15.3 +/- SEM 3.94% (p = 0.0139) after indomethacin. There was no correlation between PGE urinary excretion and GFR changes. Pre-existing renal functional impairment was not a significant risk factor. Caution should be exercised when using non-steroidal anti-inflammatory drugs in renal transplant patients.
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