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  • Title: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): cytomorphologic analysis on fine-needle aspirates.
    Author: Schmitt FC.
    Journal: Diagn Cytopathol; 1992; 8(6):596-9. PubMed ID: 1468336.
    Abstract:
    Cytomorphologic characteristics of smears from fine-needle aspirates (FNA) of three cases of sinus histiocytosis with massive lymphadenopathy (SHML) (Rosai-Dorfman disease) are described. All aspirates showed mature lymphocytes, plasma cells, and large pale histiocytes with well-preserved lymphocytes within the cytoplasm (lymphocytophagocytosis). The cases were confirmed by surgical biopsy, and the immunohistochemical findings suggested a macrophage origin for this lesion. The value of FNA analysis as an aid to diagnosis of SHML is discussed.
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