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  • Title: Arrays of immobilized oligonucleotides--contributions to nucleic acids technology.
    Author: Seliger H, Hinz M, Happ E.
    Journal: Curr Pharm Biotechnol; 2003 Dec; 4(6):379-95. PubMed ID: 14683432.
    Abstract:
    The interactions of nucleic acids technology and the technology of arrayed nucleic acids are described, showing the interdependence of nucleic acids chemistry, surface chemistry, (micro-) technology and the requirements of bio-medical applications. The methods and problems of the production of large numbers of oligonucleotides as well as the methods of arraying oligonucleotides are highlighted. The basic approaches, in-situ synthesis and postsynthetic immobilization, are described with a special emphasis on the postsynthetic immobilization of ready-made oligonucleotides on support materials. Techniques for the detection of nucleic acids interactions on arrays are outlined in brief.
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