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  • Title: Novel O-glycosyl amino acid mimetics as building blocks for O-glycopeptides act as inhibitors of galactosidases.
    Author: Kröger L, Henkensmeier D, Schäfer A, Thiem J.
    Journal: Bioorg Med Chem Lett; 2004 Jan 05; 14(1):73-5. PubMed ID: 14684301.
    Abstract:
    As potential lead structures for a new class of glycosidase inhibitors the novel O-glycosyl amino acid mimetics 3'-O-[2,6-anhydro-D-glycero-L-gluco-heptitol-1-yl]-L-serine 3 and-L-threonine 4 were synthesized, employing regio- and stereoselective aziridine ring opening methodology. They proved to be stable in the presence of glycosidases and showed competitive inhibition of alpha-galactosidase from Aspergillus niger.
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