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  • Title: Antifungal anthracycline antibiotics, spartanamicins A and B from Micromonospora spp.
    Author: Nair MG, Mishra SK, Putnam AR, Pandey RC.
    Journal: J Antibiot (Tokyo); 1992 Nov; 45(11):1738-45. PubMed ID: 1468980.
    Abstract:
    Spartanamicins A and B, two antifungal antibiotics, were produced by a culture of Micromonospora spp. strain No. MSU-43097 (ATCC 53803), isolated from a potted soil containing asparagus (Asparagus officinalis L.) plants. The antibiotics were isolated from the mycelial cake using organic solvents. The structures of spartanamicins A and B were determined by spectral and chemical means. Spartanamicin B is more active as an antifungal compound than it's analogue, A. The minimum inhibitory concentration for spartanamicin B on Candida albicans and Aspergillus, Cladosporium, Cryptococcus, Rhodotorula and Staphylococcus spp. ranged from 0.2 to 1 microgram/ml. It was not active against Staphylococcus aureus, Escherichia coli and Citrobacter spp. but some strains of S. aureus were sensitive.
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