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  • Title: Timing of fetal nucleated red blood cell count elevation in response to acute hypoxia.
    Author: Blackwell SC, Hallak M, Hotra JW, Refuerzo J, Hassan SS, Sokol RJ, Sorokin Y.
    Journal: Biol Neonate; 2004; 85(4):217-20. PubMed ID: 14691347.
    Abstract:
    We determined the effect of an acute episode of severe hypoxia on peripheral nucleated red blood cell (RBC) counts in the fetal rat. Timed pregnant rats were randomized to a 2-hour exposure to hypoxia (placement in a chamber containing a gas mixture with 9% O2 +3% CO2 + balanced N2) or to a 2-hour exposure to a sham chamber containing room air. Two maternal animals per group underwent cesarean section immediately after the 2-hour period and then 4, 12, 24, 36, 48, and 60 h after exposure. Fetal nucleated RBC counts were compared between groups at each time interval. The nucleated RBC counts were not significantly different in the hypoxia group until 12 h (mean +/- SEM 158.0 +/- 22.4 RBC/10 high-power fields vs. 90.6 +/- 11.0; p = 0.03) and 24 h (133.2 +/- 16.0 vs. 84.1 +/- 9.0; p = 0.04) after exposure. There were no differences between groups 36, 48, and 60 h after exposure. In the near-term rat fetus, acute hypoxia was associated with a delayed but transient increase in peripheral nucleated RBC counts.
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