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  • Title: Congenital Rosai-Dorfman disease without lymphadenopathy.
    Author: Iwabuchi H, Kakihara T, Tanaka A, Uchiyama M, Shibuya H, Umezu H.
    Journal: Pediatr Pathol Mol Med; 2003; 22(5):399-403. PubMed ID: 14692191.
    Abstract:
    Rosai-Dorfman disease (RDD) is a rare histiocytic proliferative disorder with massive lymphadenopathy. We here describe RDD of a neonate who presented with paleness and hepatosplenomegaly but not lymph-node swelling. Routine laboratory studies showed anemia, thrombocytopenia, and an elevated value of gamma-glutamyl transpeptidase. Histological examination of the liver revealed a proliferation of histiocytes with abundant eosinophilic cytoplasm, which were positive for S-100 protein and CD68 but not CD1a and did not reveal Birbeck granules. Radiological studies showed hepatosplenomegaly and a narrowing of the hepatic vein, which might have contributed to hypersplenism resulting in anemia and thrombocytopenia. This case is thought to be congenital RDD without lymphadenopathy.
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