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  • Title: [Effects of Semen Sojae Preparatum on lipid metabolism in ovariectomized rat].
    Author: Wang X, Ge X, Bai X, Song C, Niu L, Xu H.
    Journal: Zhong Yao Cai; 2003 Sep; 26(9):652-4. PubMed ID: 14692323.
    Abstract:
    OBJECTIVE: To investigate the antiatherosclerotic effect of Semen Sojae Preparatum (SSP) and its mechanism. METHODS: 48 rats were randomly divided into sham operation group (sham), ovariectomized group (OVX) and three doses of OVX + SSP groups. SSP was given to OVX + SSP groups 2 weeks after ovariectomy. The levels of serum lipids and lipid peroxidation were detected after 12 weeks treatment. RESULTS: SSP lowered serum oxidized-low density lipoprotein cholesterol (OX-LDL, P < 0.01), triglyceride (TG, P < 0.01) and malondialdehyde (MDA, P < 0.05 or P < 0.01), and enhanced serum high density lipoprotein cholesterol (HDL-c, P < 0.05 or P < 0.01), polipoprotein A I (apo-AI, P < 0.01) and superoxide dismutase (SOD, P < 0.01) activity. CONCLUSION: SSP had effects on regulating lipid and antioxidation. Therefore, it might inhibit atherosclerosis in ovariectomy rats.
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