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  • Title: [Optimalization of antibiotic policy in the Netherlands. VII. SWAB-guidelines for antimicrobial therapy in adults patients with infectious endocarditis].
    Author: Verhagen DW, van der Feltz M, Plokker HW, Buiting AG, Tjoeng MM, van der Meer JT, Working Party on Antibiotic Policy (SWAB).
    Journal: Ned Tijdschr Geneeskd; 2003 Dec 06; 147(49):2417-21. PubMed ID: 14694550.
    Abstract:
    The Working Party on Antibiotic Policy (Dutch acronym: SWAB) has developed guidelines for in-hospital antimicrobial therapy of adult patients with infective endocarditis. The choice and the duration of antimicrobial therapy are determined by the infecting micro-organism, the sensitivity of this micro-organism to antimicrobial therapy, the location of the endocarditis (left- or right-sided) and the presence of intracardial prosthetic material. While waiting for the culture results, the antibiotic treatment of an infected native valve is benzylpenicillin (in cases which begin subacutely or have a long history) or flucloxacillin (cases which begin acutely, are fulminant or in i.v. drug users), and gentamicin. If a prosthetic valve is infected then treatment of choice is vancomycin and gentamicin. Further antibiotic treatment depends on the causative micro-organism. Streptococci, enterococci and staphylococci are the most frequently occurring of these.
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