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  • Title: Parasitic infection of the gut and protein-losing enteropathy.
    Author: Sullivan PB, Lunn PG, Northrop-Clewes CA, Farthing MJ.
    Journal: J Pediatr Gastroenterol Nutr; 1992 Nov; 15(4):404-7. PubMed ID: 1469520.
    Abstract:
    Parasitic infection of the gut is highly prevalent in developing countries and contributes to the severe malnutrition associated with persistent diarrhoea in children. Using random faecal alpha 1-antitrypsin measurements as an index of protein-losing enteropathy, we examined children with and without parasitic infection of the gut. Seventeen percent of children with persistent diarrhoea had evidence of protein-losing enteropathy. This was found to be associated with hypoalbuminaemia in children infected with Strongyloides stercoralis. Only a minority (2 of 17) of children infected with Giardia lamblia had raised faecal alpha 1-antitrypsin excretion and this was not associated with hypoalbuminaemia. This study emphasises the need for rapid diagnosis and treatment of Strongyloides infection in children with persistent diarrhoea and severe nutrition.
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